Ashley+D.

 = Cri-du-chat syndrome (Cats Cry) =

=What is Cri-du-chat syndrome? = ·  Also known as 5p- syndrome, which is when you are missing a piece of chromosome 5. · Infants that have this syndrome usually have a high pitched cry, like a cat sound. · The disorder is usually shown by intellectual disability and delayed development, distinctive facial features, small head size, low birth weight, and weak muscle tone in infancy. · Often kids with Cri-du-chat syndrome have heart defects.  · // Cri-du-chat syndrome occurs in an estimated 1 in 20,000 to 50,000 newborns. More commonly found in females. // =Mode of Inheritance = · It is caused by a missing piece of Chromosome 5. =Clinical Description of Disorder = · The cry sounds like a kitten meowing due to problems with the larynx and nervous system. This cry identifies the syndrome. About 1/3 of children lose the cry by age 2. <span style="color: rgb(255, 128, 0); font-family: Symbol;">·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> Feeding problems because they have a hard time swallowing<span style="color: rgb(255, 128, 0);"> <span style="color: rgb(255, 128, 0); font-family: Symbol;">·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> Low birth weight and poor growth<span style="color: rgb(255, 128, 0);"> <span style="color: rgb(255, 128, 0); font-family: Symbol;">·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> <span style="color: rgb(255, 128, 0);">Severe cognitive, speech, and motor delays <span style="color: rgb(255, 128, 0); font-family: Symbol;">·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> <span style="color: rgb(255, 128, 0);">Behavior problems such as hyperactivity, aggression, tantrums, and repetitive movements <span style="color: rgb(255, 128, 0); font-family: Symbol;">·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> <span style="color: rgb(255, 128, 0);">Facial features may change over time <span style="color: rgb(255, 128, 0); font-family: Symbol;">·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> <span style="color: rgb(255, 128, 0);">Downward slanted eyes <span style="color: rgb(255, 128, 0); font-family: Symbol;">·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> <span style="color: rgb(255, 128, 0);">Small jaw

=<span style="color: rgb(54, 95, 145);">Treatment = ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> No specific treatment is available for this syndrome. ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> The mental retardation must be addressed, and counseling is recommended for the parents. ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> Parents of a child with this syndrome should have genetic counseling and a karyotype test to determine if one parent has a rearrangement of chromosome 5. =<span style="color: rgb(54, 95, 145); font-family: Cambria;">Exams & Test’s =

<span style="color: rgb(79, 129, 189); font-family: Cambria;">In addition to symptoms, the physical examination may show:
·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> [|Inguinal hernia] ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> [|Diastasis recti] (separated abdominal muscles) ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> Low muscle tone ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> [|Epicanthal folds], an extra fold of skin over the inner corner of the eye ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> Incompletely or abnormally folded external ears Genetic tests can show a missing part of chromosome 5. Skull x-ray may reveal an abnormal angle to the base of the skull.

//<span style="color: rgb(79, 129, 189); font-family: Cambria;">There is no known Preventions of Cri-du-chat Syndrome //
=<span style="color: rgb(54, 95, 145); font-family: Cambria;">Support Groups = ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> 5P- Five P Minus Society ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> Cri-du-Chat Syndrome Support Group ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> Daily Strength ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> Cri - Du - Chat Syndrome 5p-

=<span style="color: rgb(54, 95, 145); font-family: Cambria;">References = ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> [] ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> [|www.**cri**d**chat**.u-net.com/] ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> [|www.fivepminus.org/] ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> [|www.familyvillage.wisc.edu/Lib_**cri**c.htm] ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> [|www.mdjunction.com/**cri**-**du**-**chat**-syndrome] ·<span style="font-family: 'Times New Roman'; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"> [|www.ibis-birthdefects.org/start/**cridu**cha.htm]

<span style="color: rgb(54, 95, 145); font-family: Cambria;">**Pictures Of Kids With Cri-du-chat Syndrome:**
<span style="color: rgb(54, 95, 145); font-family: Cambria;"> =<span style="color: rgb(54, 95, 145); font-family: Cambria;">Pictures Of What The Chromosomes Look Like: =

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