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** __Introduction: What is Osteogenesis Imperfecta?__ **
Osteogenesis Imperfecta is a group of genetic disorders that mainly affect the bones. A person is born with this disease and is affected throughout his or her life. A classification system of different types of OI is commonly used to describe how severely a person is affected with OI. Other names that Osteogenesis Imperfecta is commonly known by :
 * 1) Brittle Bone disease
 * 2) Ekman Lobstein disease
 * 3) Fragilitas Ossium
 * 4) OI
 * 5) Osteopsathyrosis
 * 6) Vrolik disease

__Types of Osteogenesis Imperfecta__
__**Type 1**__ This is the most mild of OI. It is autosomal dominant in its inheritance, but it can also result from mutation. Some of features of this type is: This is the type that is most severe form of this disease. The bones of people with this type are extremely fragile and they often have deformities. This type usually causes death at or shortly at birth. __**Type 3**__ This is a result from spontaneous mutation and it is common for a person to have experienced 100 fractures by the time he or she reaches puberty. Some features of type 3 are: __**Type 4**__ This type is inherited in an autosomal dominant manner. Fractures are most common in OI type 4 before puberty. The features of type 4 are:
 * 1) fragile bones
 * 2) triangular-shaped face
 * 3) hearing loss beginning in the 20's
 * 4) thin, smooth skin
 * 5) loose joints
 * 6) low muscle tone
 * 7) brittle teeth
 * __Type 2__**
 * 1) loose joints
 * 2) poor muscle development
 * 3) triangular-shaped face
 * 4) scoliosis
 * 5) possible hearing loss
 * 6) poor teeth development
 * 1) below average height
 * 2) barrel-shaped ribcage
 * 3) possible hearing loss
 * 4) possible brittle teeth
 * 5) loose, easily overstreched joints

**__Clinical Description of Disorder__**
The symptons of OI vary a great deal. The symptons of OI are: In the most severe forms of OI, there may be bone deformities, poor lung development and lung problems, a barrel-shaped chest, poor muscle development in the arms and legs.
 * 1) Bones that break easily (most before puberty)
 * 2) Brittle teeth
 * 3) Changes in the white of the eyes
 * 4) Height that ranges from shorter than average to normal
 * 5) Loose joints and muscle weakness
 * 6) Loss of hearing in the early 20's and 30's
 * 7) Triangular face

__** Causes, Risk Factors, and Diagnosing of OI **__
OI is caused by a faulty gene that affects the body's ability to produce collagen. If one parent has OI, a child has a 50% chance of having OI. Biochemical (collagen) or molecular (DNA) tests can help confirm the diagnosis in nearly 90% of all type 1 cases. A negative test doesn't necessarily rule out the possibility of a child having another form of OI or type 1 OI that couldn't be detected by the test. =__Treatment__ There is no cure for OI. But the treatment focuses on managing the symptons, preventing complications, developing bone mass, and muscle strength. Pain management is an improtant tool in helping to assure that a person with OI is able to manage their condition and live a normal life. Certain drugs can be helpful with OI and eating a nutritious diet is recommended. =    Support Groups for O I
 * __The Osteogenesis Imperfecta Foundation Inc.__ is a national health organization dedicated to improve the lives of people by education, support, and research to improve treatments.
 * __Osteogenesis Imperfecta Support Group of Wisconsin__ provides support for families of children of OI.
 * The Osteogenesis Imperfecta Foundation is dedicated to helping people cope with OI>

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**__Refrences__**

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