Matthew+D.



Prader- Willi Syndrome 
 * This disease is also known as PWS or Prader-Labhart-Willi Syndrome.

//__The Mode of Inheritance __// 
 * The genetic disorder __Prader-Willi Syndrome__ is autosomal dominant.
 * The chromosomal error that occurs in this disease is the deletion of seven genes on chromosome number 15.

The mode of inheritance for this disease is random. Genes on the 15th chromosome are missing when the child is born. In rare cases the abnormality in the chromosome is passed to the offspring.  This is a picture of one leg of the 15th chromosome. It points out which genes are missing.

Infancy: Some of the symptoms at this age are weak muscle tone, problems feeding, and slow development.
 * __SYMPTOMS__

Childhood: The symptoms get worse as the child gets older. They begin to include things such as unsatisfiable appetite, Hyperhagia or overeating, behavioral problems, mental retardation, and lack of height. Adulthood: During the rest of the person's life they keep many of these symptoms. Some other symptoms become apparent such as being sexually underdeveloped and not being able to conceive children. ||

media type="youtube" key="Vr5nSFf2p2Y" height="344" width="425"media type="youtube" key="HUeHS4HNIbc" height="344" width="425" The location of the defect/ mutation is in the 15th chromosome. It affects the victim both physically and mentally. It causes them to want to keep eating and never stop and it also causes mental retardation.
 * > __Clinical Description__

This disorder can be life threatening. In some cases it can lead to death.

This disorder occurs in 1 out of every 8,000 up to 1 out of every 25,000.

It is found equally between genders and it is not found in one certain ethnic group.

The disease is diagnosed through genetic testing. It was first observed in 1956 by Andrea Prader, Heinrich Willi, Alexis Labhart, Andrew Ziegler, and Guido Fanconi.

The disorder can be detected before the symptoms through genetic testing.

__Treatment__ There is no cure for the disorder but the victim has to have a very strict diet and should be kept away from areas where there is food. It is better if the victim is housed with other victims so that no one has access to the food more than the others in the household.

There is ongoing research at the time that is taking place mainly in Canada. || Support Groups
 * Prader-Willi Association ([|www.pwsausa.org/support/index.htm])
 * [|www.mdjunction.com/prader-willi-syndrome]
 * <span style="display: block; font-size: 120%; color: rgb(0, 0, 255); font-family: 'Arial Black',Gadget,sans-serif; text-align: left;">[|www.dailystrength.org/c/Prader-Willi-Syndrome/support-group]

<span style="font-size: 120%; font-family: 'Arial Black',Gadget,sans-serif; color: rgb(0, 0, 128);"> Works Cited

"Prader-Willi Syndrome." MedicineNet.com. 2 Apr. 2009 <http://www.medicinenet.com/prader-willi_syndrome/article.htm>.

"Prader-Willi Syndrome." MedicinePlus. 2 Apr. 2009 <http://www.nlm.nih.gov/medlineplus/praderwillisyndrome.html>.

"Prader-Willi Syndrome." Prader-Willi Association. Prader-Willi Association. 1 Apr. 2009 <www.pwsausa.org>.

"Prader-Willi Syndrome." Wikipedia. 2 Apr. 2009 <http://en.wikipedia.org/wiki/Prader-Willi_syndrome>.